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KMID : 0359920080270050600
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Korean Journal of Nephrology
2008 Volume.27 No. 5 p.600 ~ p.605
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Two Cases of Nephrolithiasis Following Administration of Cyclosporine
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Park Ji-Young
Kim Seung-Jung
Kang Duk-Hee
Choi Kyu-Bok
Yoon Kyun-Il
Ryu Jung-Hwa
Ryu Dong-Ryeol
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Abstract
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Cyclosporine is one of the most useful immunosuppressants for many diseases including nephrotic syndrome, glomerulonephritis, organ transplantation, and other autoimmune diseases. However, cyclosporine is known to cause renal tubular acidosis (RTA) due to a decrease in urinary ammonium excretion. Cyclosporine also can lead to significant hypocitraturia due to a higher proximal tubular reabsorption of citrate and increase the risk for nephrolithiasis. Citrate excretion is essential for the prevention of urinary supersaturation and hypocitraturia is a major risk factor for nephrocalcinosis and nephrolithiasis. Now we report two cases of nephrolithiasis treated with cyclosporine. The first patient is a renal transplantation recipient and the second patient has membranous glomerulonephritis. Therefore, these two cases lead us to conclude that patients treated with cyclosporine have to be regularly followed up for nephrolithiasis caused by cyclosporine-induced tubular dysfunction.
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KEYWORD
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Cyclosporine, Citrate, Nephrolithiasis, Nephrocalcinosis
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